One triterpenoid and five phenolic compounds from the liverwort Bazzania sp.

Abstract

Introduction: The Bazzania genus , a type of liverwort known as a low-level herbaceous organism, comprises approximately 250 species. Only 8 species have been chemically and biologically studied worldwide, and none have been studied in Vietnam. This paper described the isolation and structure elucidation of six compounds isolated from the liverwort Bazzania sp. collected in Lac Duong district, Lam Dong Province, Vietnam, in July 2020. Methods: Phytochemical investigations of the n-hexane and chloroform extracts of Bazzaniasp. led to the isolation of six pure compounds. Their chemical structures were elucidated by HR-ESI-MS, 1D and 2D-NMR spectroscopic analysis and comparison with previously published data. Results: From the studied liverwort Bazzania sp ., six compounds, namely, cycloartenol ( 1 ) and five phenolic derivatives, p-coumaric acid ( 2 ), p-hydroxybenzoic acid ( 3 ), methyl 2,4-dihydroxy-3,6-dimethylbenzoate ( 4 ), barbatic acid ( 5 ), and methyl 2-hydroxy-4-methoxy-6-tetradecylbenzoate ( 6 ), were isolated and structurally elucidated. Conclusions: Although these compounds are known in other species, this is the first time they have been reported in Bazzania sp.