Potential Conscientious Objection to mRNA Technology as Preventive Treatment for COVID-19

P. Provost, N. Derôme, C. Linard, B. Massie, Jean Caron
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引用次数: 1

Abstract

In the context of mass vaccination campaigns, the most widely used vaccines in Western countries are based on messenger RNA (mRNA). Some countries have imposed mandatory vaccination and many others have required a vaccination passport to access public transportation and many activities, producing systemic discrimination, social exclusion, segregation, and stigmatization against non-vaccinated individuals. This paper aims to present several scientific uncertainties on which, conscientious objectors to mRNA injections as a preventive treatment for COVID-19, could rely. Scientific data are presented on mRNA vaccines, which consist in mRNAs wrapped in lipid nanoparticles. Never used as a prophylactic drug, artificial mRNAs delivered to our cells forces them to express, against their nature, a biologically active viral protein. Unlike a drug produced in a pharmaceutical factory and formulated at a known dose and a well-defined protein product profile, the mRNA vaccine acts as a pro-drug encoding for the viral Spike protein of the virus to be produced by our own cells; both the dose and the quality of the proteins produced are unknown. We also ignore the distribution of the lipid nanoparticles carrying this mRNA in our body. We consider that the “conscientious objection” raised by the above considerations is a reason enough to refuse mRNA vaccines or similar technologies as a preventive treatment against COVID-19.
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对mRNA技术作为COVID-19预防性治疗的潜在良心反对
在大规模疫苗接种运动的背景下,西方国家最广泛使用的疫苗是基于信使RNA (mRNA)的疫苗。一些国家强制接种疫苗,许多其他国家要求接种疫苗护照才能乘坐公共交通工具和参加许多活动,从而对未接种疫苗的个人产生系统性歧视、社会排斥、隔离和污名化。本文旨在提出几个科学上的不确定性,出于良心拒服兵役者可以依靠mRNA注射作为COVID-19的预防性治疗。科学数据提出了mRNA疫苗,其中包括包裹在脂质纳米颗粒的mRNA。人造mrna从未被用作预防药物,它被送到我们的细胞中,迫使它们违背自身的本性,表达一种具有生物活性的病毒蛋白。与制药厂生产的已知剂量和明确定义的蛋白质产物谱的药物不同,mRNA疫苗作为病毒刺突蛋白的前药物编码,由我们自己的细胞产生;产生的蛋白质的剂量和质量都是未知的。我们也忽略了携带这种mRNA的脂质纳米颗粒在我们体内的分布。我们认为,上述考虑所提出的“良心反对”足以成为拒绝mRNA疫苗或类似技术作为COVID-19预防性治疗的理由。
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