Synthesis and central pharmacological screening of new aminoalkoxy derivatives of coumarin and chromene.

S Suski, T Zawadowski, M Bogdal, B Przemyk, B Szafrański
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Abstract

Several 8-(2- and 3-aminoalkoxy) derivatives of coumarin and 5-(2- and 3-aminoalkoxy) derivatives of chromene have been synthesized. The strongest, although short-time neurodepressive activity was exhibited by 8-[3-(4-phenyl-1-piperazinyl)propoxy]-7-methoxycoumarin hydrochloride 15.

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香豆素和铬新氨基烷氧基衍生物的合成及中心药理筛选。
香豆素的8-(2-和3-氨基烷氧基)衍生物和铬的5-(2-和3-氨基烷氧基)衍生物已被合成。8-[3-(4-苯基-1-哌嗪基)丙氧基]-7-甲氧基香豆素的神经抑制作用最强,但时间较短。
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