Sleeve Gastrectomy in Canine: Effect on Weight Loss, Inflammation andOxidative Stress Markers while Leaving Blind Intestinal Loop in Place

Abstract

The aim of this study was to modify the current Sleeve gastrectomy surgical procedure by leaving behind the blind intestinal loop, with the purpose to overcome the complications of gastric bypass. Accordingly, we evaluated in Canine, the effectiveness of this approach, on the weight loss and markers of inflammation and oxidative stress. Our results suggest that this type of bypass surgery in Canine resulted in significant weight loss that was maintained up to six months. There was no evidence of post-operative leaks, infection or organ adhesion. However, oxidative stress and inflammation markers were elevated in the post-operative stomach but not in the nonfunctional blind intestinal loop, six months after surgery. Elevation of these markers, post surgically in the target organ suggesting that it may take longer time for these markers to come back to healthy pre-operative levels. The purpose of leaving behind the blind intestinal loop may allow reversing the bypass in future date due to any unintended complications such as excessive weight loss.