[The characteristics of the correlation of the functional activity, blood supply and structural organization in the sensory-deprived cerebral cortex in rats].

Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova Pub Date : 1992-11-01

Iu E Moskalenko, I A Zhuravin, T V Riasina, N D Zaiats, G S Kilibaeva, V N Semernia

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Abstract

The feature of correlation between functional activity of the brain tissue and structural-functional characteristics of the vascular system after sensory deprivation by the removal of whiskers in newborn animals were studied in nembutal-anaesthetized rats in comparison to the animals under d-tubocurarine with local anesthesia. It has been shown that there are major changes of EP parameters and ECoG in the sensory-deprived brain area and diminution of brain cortex thickness. Changes in the vascular system are mainly structural, what are revealed as disorganization in angioarchitecture of radial arteries. At the same time, differences in the blood circulation intensity are found in d-tubocurarine animals only. The largest volume of the local blood circulation is observed in intact hemisphere of sensory-deprived animal. Thus, it can be concluded that sensory-deprived model is the alternative to the ischemia model. This model can be used in studies of physiology of brain blood circulation, and the "structure-function" correlation, in particular.

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[感觉剥夺大鼠大脑皮层功能活动、血供与结构组织的相关性特征]。

本文研究了新生动物感觉剥夺去须后，以戊巴丁醚麻醉大鼠为研究对象，并与局部麻醉d-管碱麻醉大鼠进行比较，观察其脑组织功能活动与血管系统结构功能特征的相关性。结果表明，感觉剥夺脑区EP参数和ECoG发生较大变化，脑皮层厚度减小。血管系统的改变主要是结构性的，表现为桡动脉血管结构的紊乱。同时，血液循环强度的差异只存在于d-管碱动物身上。在感觉剥夺动物的完整半球，局部血液循环容量最大。因此，感觉剥夺模型可以替代缺血模型。该模型可用于脑血液循环生理学的研究，特别是“结构-功能”相关性的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova

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