SPR based biosensor for the detection of abnormal growth of tissues

Abstract

Detection of cancer in early stage is what the top priority in the field of medical. This early stage detection of cancer can lead to much added benefits and also a life saving technique. In this paper, a 2-dimensional SPR based sensor is designed for thorough spectral analysis of “Leukemia”. As dielectric properties of the cancer cells differ from the normal cell, they can be differentiated and detected using photonic approach. In the present work, SPR technique is done and the simulation is done to analys the sensor using Eand H fields. The shifts in the output waveforms and frequencies have been observed for a normal blood cell and that with a cancerous cell. Its clear from simulation that for minor change of RI of the biosample taken into consideration there will be shift in the resonant frequency therefore exhibiting an biosensor. The designed sensor can distinguish between normal and cancerous cell. This indicates its high sensitiveness even for minute change in refractive index. The achieved sensor has an sensitivity of 343 nm/RIU.