Automatic segmentation of brain MR images for patients with different kinds of epilepsy

Abstract

Idiopathic generalized epilepsy (IGE) and symptomatic generalized epilepsy (SGE) are two kinds of generalized epilepsy. In this study, we discussed the methods of automatically segmentation of MR images for patients with these two kinds of epilepsy. K-Means clustering, expectation-maximization, and fuzzy c-means algorithms were employed to perform segmentation on brain images for patients with IGE. For patients with SGE, a trimmed likelihood estimator combined with Gaussian mixture model, which we improved based on other's existing work, was employed to detect obvious brain lesions on fluid-attenuated inversion recovery images. Gray matter, white matter, and cerebrospinal fluid were then segmented from the remaining normal brain part. Similarity metrics were used to evaluate the performance of the different segmentation methods. The Dice similarity coefficient of the segmentation results exceeded 70% and satisfied the basic clinical requirement. Actually, the segmentation results were acceptable to clinicians and can provide clinicians more disease information to diagnose and treat epilepsy.