{"title":"Combined effects of flavonoids and acyclovir against herpesviruses in cell cultures.","authors":"I Mucsi, Z Gyulai, I Béládi","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The combined antiviral effects of some flavonoid compounds and acycloguanosine (acyclovir, Zovirax) were studied on the multiplication of herpes simplex virus types 1 and 2 in HEp-2 cells and on pseudorabies (Aujeszky) virus in chick embryo fibroblast cells by the yield reduction method. The flavonoids quercetin, quercitrin (quercetin-3-L-rhamnoside) and apigenin exhibit antiviral activity against these herpesviruses, and acyclovir is currently one of the most effective antiherpetic agents. In these studies, the simultaneous application of flavonoids with acyclovir resulted in an enhanced antiviral activity. A mathematical formula was used to interpret the drug interaction, resulting in FIC (fractional inhibitory concentration) indices. Meaning a synergic interaction, all combinations exhibited synergy, FIC values of 0.6-0.8 being commonly observed.</p>","PeriodicalId":76970,"journal":{"name":"Acta microbiologica Hungarica","volume":"39 2","pages":"137-47"},"PeriodicalIF":0.0000,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta microbiologica Hungarica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The combined antiviral effects of some flavonoid compounds and acycloguanosine (acyclovir, Zovirax) were studied on the multiplication of herpes simplex virus types 1 and 2 in HEp-2 cells and on pseudorabies (Aujeszky) virus in chick embryo fibroblast cells by the yield reduction method. The flavonoids quercetin, quercitrin (quercetin-3-L-rhamnoside) and apigenin exhibit antiviral activity against these herpesviruses, and acyclovir is currently one of the most effective antiherpetic agents. In these studies, the simultaneous application of flavonoids with acyclovir resulted in an enhanced antiviral activity. A mathematical formula was used to interpret the drug interaction, resulting in FIC (fractional inhibitory concentration) indices. Meaning a synergic interaction, all combinations exhibited synergy, FIC values of 0.6-0.8 being commonly observed.
采用产量还原法研究了几种黄酮类化合物与无环鸟苷(无环鸟苷、Zovirax)联合抗病毒HEp-2细胞中1型和2型单纯疱疹病毒和鸡胚成纤维细胞中伪狂犬病病毒的增殖作用。槲皮素类黄酮、槲皮素(槲皮素-3- l -鼠李糖苷)和芹菜素对这些疱疹病毒具有抗病毒活性，而无环鸟苷是目前最有效的抗疱疹药物之一。在这些研究中，黄酮类化合物与阿昔洛韦同时应用导致抗病毒活性增强。用数学公式解释药物相互作用，得到FIC(分数抑制浓度)指数。这意味着协同作用，所有组合都表现出协同作用，通常观察到FIC值为0.6-0.8。
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