[Rare opportunistic fungal diseases in patients with organ or bone marrow transplantation].

R Herbrecht, J Waller, P Dufour, H Koenig, B Lioure, L Marcellin, F Oberling
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引用次数: 0

Abstract

Candidiasis, aspergillosis and cryptococcosis are the most common fungal infections in transplant recipients. However other fungal infections have been reported. Mucormycosis, Scedosporium infections, fusariosis and trichosporonosis represent the largest part of these rare mycosis. The clinical and mycological features are described here. In addition, cases of very uncommon mycosis, most of them only once reported, have been reviewed. Overall the diagnosis is difficult as mycological examinations are often negative till the disease is disseminated. Amphotericin B remains the reference treatment except in Scedosporium infections which respond more likely to azole antifungal agents. Despite the treatment the outcome is usually fatal.

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[罕见的器官或骨髓移植患者机会性真菌病]。
念珠菌病、曲霉菌病和隐球菌病是移植受者中最常见的真菌感染。然而,其他真菌感染也有报道。毛霉病、塞多孢子菌感染、镰孢病和三磷菌病是这些罕见的真菌病的最大部分。临床和真菌学特征在此描述。此外,病例非常罕见的真菌病,其中大多数只报道过一次,已经审查。总的来说,诊断是困难的,因为真菌学检查通常是阴性的,直到疾病扩散。两性霉素B仍然是参考治疗,除了对塞多孢子菌感染更可能对唑类抗真菌药物有反应。尽管进行了治疗,但结果通常是致命的。
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