A comparative study of nabumetone and indomethacin in ankylosing spondylitis.

T G Palferman, M Webley
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Abstract

Forty-two patients with ankylosing spondylitis were entered into a double-blind study to compare treatment with indomethacin and a new non-steroidal anti-inflammatory drug, nabumetone. Clinical, laboratory and side-effect profiles were measured over a three month period. Both drugs were effective in relieving pain and morning stiffness, indomethacin was better in alleviating general stiffness, nabumetone resulted in less side-effects. Objective measurements of spinal movements revealed no difference between the two drugs. Nabumetone, available as Relifex, appears as effective as indomethacin in relieving the symptoms of ankylosing spondylitis and is possibly better tolerated.

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纳布美酮与吲哚美辛治疗强直性脊柱炎的比较研究。
42名强直性脊柱炎患者进入了一项双盲研究,比较吲哚美辛和一种新的非甾体抗炎药纳布美酮的治疗效果。在三个月的时间里测量了临床、实验室和副作用的概况。两种药物均能有效缓解疼痛和晨僵,吲哚美辛缓解全身僵硬效果较好,纳布美酮副作用较小。脊髓运动的客观测量显示两种药物之间没有差异。在缓解强直性脊柱炎的症状方面,纳布美酮与吲哚美辛一样有效,而且耐受性可能更好。
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