Eukaryotic gene regulation: simple vs complex models.

Abstract

The current generally accepted model of eukaryotic gene regulation is essentially a simple one. Regulatory proteins containing separable DNA binding and transcriptional activation domains, bind to specific DNA sequences in promotors and interact directly or indirectly with the TATA Box binding factor to increase the rate of transcription initiation at selected promotors. Here we present observations suggesting that the process may be more complex.