[Regular Paper] Identification of Several Core Overexpressed MicroRNAs that Could Predict Survival in Patients with Ovarian Cancer

2018 IEEE 18th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2018-10-01 DOI:10.1109/BIBE.2018.00058

E. Dessie, Ezra B. Wijaya, Chien-Hung Huang, D. Agustriawan, J. Tsai, K. Ng

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引用次数: 1

Abstract

MicroRNAs as biomarkers play an important role in the oncogenesis process, including ovarian cancer. The objective of this study is to evaluate the miRNAs overexpression association with survival of ovarian cancer patients. MiRNA expression levels between tumor and normal samples were compared using t-test. Differentially expressed miRNAs were selected (p-value ≤ 0.001) and only 195 up-regulated miRNAs for 565 ovarian cancer samples were further analyzed using multivariate Cox regression and survival random forest. The median survival time for ovarian cancer patient was 33.64 months. The result of survival random forest and multivariate Cox regression showed that high level expression of nine miRNAs were associated with shorten survival of ovarian cancer patients; whereas high level expression of hsa-miR-154* was significantly correlated with a prolonged overall survival ovarian cancer patients. These nine aberrantly overexpressed miRNAs that resulted shorter survival time may play important roles in oncogenesis, growth, and metastasis of ovarian cancer. Hence, these findings may be used as novel prognostic biomarkers and therapeutic targets for ovarian cancer patients.

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【常规论文】几种核心过表达microrna的鉴定可预测卵巢癌患者的生存

microrna作为生物标志物在肿瘤发生过程中发挥着重要作用，包括卵巢癌。本研究的目的是评估miRNAs过表达与卵巢癌患者生存的关系。采用t检验比较肿瘤与正常样本的MiRNA表达水平。选择差异表达的mirna (p值≤0.001)，使用多变量Cox回归和生存随机森林对565例卵巢癌样本中仅195个上调mirna进行进一步分析。卵巢癌患者的中位生存期为33.64个月。生存随机森林和多因素Cox回归结果显示，9种mirna的高表达与卵巢癌患者生存期缩短相关;而高水平表达hsa-miR-154*与卵巢癌患者总生存期的延长显著相关。这9个异常过表达的mirna导致存活时间缩短，可能在卵巢癌的发生、生长和转移中发挥重要作用。因此，这些发现可能作为卵巢癌患者新的预后生物标志物和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2018 IEEE 18th International Conference on Bioinformatics and Bioengineering (BIBE)

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