Diaspirin cross-linked hemoglobin solution as a resuscitative fluid following severe hemorrhage in the rat.

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI:10.3109/10731199209119674

D Malcolm, D Kissinger, M Garrioch

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引用次数: 25

Abstract

The effect of diaspirin cross-linked hemoglobin (DCLHb) on mean arterial pressure (MAP) and heart rate (HR) was compared to Ringer's lactate (RL) and shed blood in a 70% lethal model of hemorrhage (35 cc/kg blood loss) in conscious rats. All animals resuscitated with DCLHb regardless of dose (17.5 and 35 cc/kg) and concentration (7% and 10% solution) exhibited complete restoration of MAP and HR which was maintained for at least 5 hrs. Hemodynamic responses in DCLHb-treated animals were not significantly different from 35 cc/kg blood-treated animals. In RL (105 cc/kg) treated animals the MAP was restored to 60-70% of baseline. 24 hr survival in animals resuscitated with fluids ranged between 88-100% and was not significantly different between treatment groups.

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双阿斯匹林交联血红蛋白液在大鼠大出血后的复苏作用。

采用清醒大鼠70%致死性出血模型(35 cc/kg失血量)，比较双阿斯匹林交联血红蛋白(DCLHb)对平均动脉压(MAP)和心率(HR)的影响。所有用DCLHb复苏的动物，无论剂量(17.5和35 cc/kg)和浓度(7%和10%溶液)，都能完全恢复MAP和HR，并维持至少5小时。dclhb处理动物的血流动力学反应与35cc /kg血液处理动物无显著差异。在RL (105 cc/kg)处理的动物中，MAP恢复到基线的60-70%。液体复苏动物的24小时存活率在88-100%之间，治疗组之间无显著差异。

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Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology

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