Some aspects of perfluorochemical emulsion's interaction with blood.

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Pub Date : 1992-01-01 DOI:10.3109/10731199209119754

E V Tereshina, N N Doronina, N I Afonin, I N Ozerova, I A Tcherbacova

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引用次数: 2

Abstract

FDC/FTPA (7:3) emulsions stabilized by procsanol (Emulsion 1) and by procsanol with yolk phospholipids (Emulsion 2) were incubated with the donor plasma. After the incubation during 6 hours of Emulsions 1 and 2 with plasma the 36% and 50% decrease of the cholesterol content in plasma was found. Analysis of the lipid content of lipoproteins after the Emulsion 2 administration to rats (2.5 ml/100 g of weight) revealed the 50% decrease of the cholesterol amount in the HDL fraction at 3 and 24 hours posttransfusion. The ratio cholesterol/total phospholipids in the erythrocyte membrane diminished up to 50% as well. The equal degree of the cholesterol adsorption by emulsion from plasma, HDL of rats and erythrocyte membrane is an evidence of nonspecific interaction of PFC particles with the blood components containing cholesterol.

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全氟化学乳剂与血液相互作用的几个方面。

用procsanol稳定的FDC/FTPA(7:3)乳状液(乳状液1)和procsanol -蛋黄磷脂稳定的FDC/FTPA乳状液(乳状液2)与供体血浆孵育。乳剂1和乳剂2与血浆孵育6小时后，血浆中胆固醇含量分别下降36%和50%。对大鼠注射乳剂2 (2.5 ml/100 g体重)后的脂蛋白脂质含量分析显示，在输血后3和24小时，高密度脂蛋白部分的胆固醇含量降低了50%。红细胞膜中胆固醇/总磷脂的比值也降低了50%。乳剂对血浆、大鼠高密度脂蛋白和红细胞膜的胆固醇吸附程度相等，证明PFC颗粒与含胆固醇的血液成分具有非特异性相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology

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