{"title":"Comparison of the biodistribution of 75Se- and 131I-labelled monoclonal antibodies in nude mice","authors":"Jakobína Grétarsdóttir , Eva Forssell Aronsson , Lars Jacobsson , Ólöf Hafsteinsdóttir , Stig Holmberg , Larsolof Hafström , Sture Lindegren , Börje Karlsson , Leif Lindholm , Sören Mattsson","doi":"10.1016/0883-2897(92)90131-H","DOIUrl":null,"url":null,"abstract":"<div><p>A monoclonal antibody, C-215, against colon cancer, was internally labelled with [<sup>75</sup>Se]methionine. The biodistribution was studied in tumour-bearing nude mice and compared with the biodistribution of [<sup>131</sup>I]C-215. The tissue uptake was divided into three parts: antibody bound to the antigen, antibody in the extracellular space and uptake of the released radionuclide. [<sup>75</sup>Se]C-215 showed a greater amount of antigen-bound antibody in the tumour, but also a greater unspecific uptake both in tumour and normal tissue.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 7","pages":"Pages 719-726"},"PeriodicalIF":0.0000,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90131-H","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/088328979290131H","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
A monoclonal antibody, C-215, against colon cancer, was internally labelled with [75Se]methionine. The biodistribution was studied in tumour-bearing nude mice and compared with the biodistribution of [131I]C-215. The tissue uptake was divided into three parts: antibody bound to the antigen, antibody in the extracellular space and uptake of the released radionuclide. [75Se]C-215 showed a greater amount of antigen-bound antibody in the tumour, but also a greater unspecific uptake both in tumour and normal tissue.
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