C.A. Roth, T.J. Hoffman, M. Corlija, W.A. Volkert, R.A. Holmes
{"title":"The effect of ligand structure on glutathione-mediated decomposition of propylene amine oxime derivatives","authors":"C.A. Roth, T.J. Hoffman, M. Corlija, W.A. Volkert, R.A. Holmes","doi":"10.1016/0883-2897(92)90140-T","DOIUrl":null,"url":null,"abstract":"<div><p>Tetramethylpropyleneamine oxime (TMPAO) was synthesized and complexed to <sup>99m</sup>Tc. <sup>99m</sup>Tc-TMPAO samples, when challenged with reduced glutathione (GSH), were shown to have two GSH sensitive components, similar to a mixture of <em>d</em>,<em>l</em> and meso <sup>99m</sup>Tc-HMPAO. One component had a GSH-induced second-order dissociation rate constant (<em>K</em><sub>2</sub>) similar to <sup>99m</sup>Tc-meso-HMPAO. Despite the presence of a large fraction of this component in these samples, brain uptake and autoradiographic studies with <sup>99m</sup>Tc-TMPAO were equivalent to <sup>99m</sup>Tc-<em>d,l</em>-HMPAO suggesting that both the <em>d</em>,<em>l</em> and meso <sup>99m</sup>Tc-TMPAO isomers are efficiently trapped in brain.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 7","pages":"Pages 783-790"},"PeriodicalIF":0.0000,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90140-T","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/088328979290140T","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
Tetramethylpropyleneamine oxime (TMPAO) was synthesized and complexed to 99mTc. 99mTc-TMPAO samples, when challenged with reduced glutathione (GSH), were shown to have two GSH sensitive components, similar to a mixture of d,l and meso 99mTc-HMPAO. One component had a GSH-induced second-order dissociation rate constant (K2) similar to 99mTc-meso-HMPAO. Despite the presence of a large fraction of this component in these samples, brain uptake and autoradiographic studies with 99mTc-TMPAO were equivalent to 99mTc-d,l-HMPAO suggesting that both the d,l and meso 99mTc-TMPAO isomers are efficiently trapped in brain.
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