{"title":"Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate","authors":"P.R. Singh , M. Corlija , D.E. Troutner , A.R. Ketring , W.A. Volkert","doi":"10.1016/0883-2897(92)90141-K","DOIUrl":null,"url":null,"abstract":"<div><p>Diaminedithiols (DADT) are known to form neutral-lipophilic complexes with <sup>99m</sup>Tc in aqueous solutions, where they are readily formed in high yields and demonstrate excellent stability. A new triaminedithiol (TADT) ligand was synthesized, characterized and shown to form a neutral-lipophilic <sup>99m</sup>Tc-chelate. The biodistribution of this <sup>99m</sup>Tc chelate in rats showed that its uptake in brain or heart following i.v. injection of the <sup>99m</sup>Tc chelate was low, but activity taken up was retained over a long period of time. The <em>in vivo</em> and <em>in vitro</em> properties of this chelate indicate the possibility that chemical modification of this TADT ligand may produce ligand systems that form <sup>99m</sup>Tc chelates with suitable diagnostic properties.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 7","pages":"Pages 791-795"},"PeriodicalIF":0.0000,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90141-K","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/088328979290141K","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Diaminedithiols (DADT) are known to form neutral-lipophilic complexes with 99mTc in aqueous solutions, where they are readily formed in high yields and demonstrate excellent stability. A new triaminedithiol (TADT) ligand was synthesized, characterized and shown to form a neutral-lipophilic 99mTc-chelate. The biodistribution of this 99mTc chelate in rats showed that its uptake in brain or heart following i.v. injection of the 99mTc chelate was low, but activity taken up was retained over a long period of time. The in vivo and in vitro properties of this chelate indicate the possibility that chemical modification of this TADT ligand may produce ligand systems that form 99mTc chelates with suitable diagnostic properties.
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