Silodosina en el tratamiento de los síntomas del tracto urinario inferior en el varón por hiperplasia benigna de próstata: enfoque estándar y uso en la «vida real»

Abstract

Lower urinary tract symptoms (LUTS) are very frequent in men, especially in those above 65 years of age. Benign prostatic hyperplasia (BPH) is the pathology most associated with LUTS in men and is a frequent cause of altered quality of life. Monotherapy with alpha blockers is the treatment of choice in patients with moderate-to-severe LUTS secondary to BPH.

Silodosin is currently the most uroselective alpha blocker acting on the α1A receptors. Its uroselectivity has been confirmed in different in vitro, as well as in vivo, studies. The present study analyzed the main benefits of silodosin in phase iii clinical trials (standard approach) and in «real life» (analyzing the «Silodosin in Real-life Evaluation (SiRE)» phase iv trial) to validate the registrational trials and confirm the positive risk-benefit profile of silodosin in an environment that can more closely reflect clinical practice.