Is Affordability and Accessibility All It Takes?

Caroline Gregory, Michael Ogundeji, Aarti Srivastava, Bianca Vanier, Sailly Dave, A. Rampersad
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Abstract

The Affordable Medicine Facility – malaria (AMFm) was a pilot project established to subsidize quality-assured artemisinin-based combination therapies (QAACTs) in eight malaria-endemic African regions: Kenya, Uganda, Ghana, Niger, Nigeria, Madagascar, Tanzania (mainland) and Zanzibar. The objectives of the program were to increase the affordability and availability of artemisimin-based combination therapies (ACT), as well as the market share relative to other less effective antimalarial medicines. Overall, the AMFm program had a greater impact in the private-for-profit sector than the public sector. In general, public services do not work as well as their private counterparts in most countries. Inadequate services in remote areas necessitate prohibitively long journeys to access resources and care. In general, the private sector was able to provide supplies of ACTs, as long as it was profitable. Seven countries showed significant increases in availability in the private sector, six regions had significant decreases in QAACT cost, with declines ranging from $1.28 to $4.82, and all eight regions had increases in market share. Impact in remote regions was substantial, with 60% (Ghana) and 48.5% (Kenya) of facilities in remote areas stocking QAACTs. Negotiations with manufacturers, the involvement of the private sector, and supporting interventions were critical in the success of AMFm. The AMFm pilot project then transitioned into a private sector co-payment mechanism involving only six countries. The AMFm program was not sustainable due to the enormous costs of the program, potentially due to unnecessary and excessive orders of ACTs, with an estimated total of 500 million USD. Fixing this sustainability issue would make a program such as this one more applicable to other malaria-endemic countries, which have limited financial resources.
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可负担性和可获得性就够了吗?
负担得起的药物基金——疟疾(AMFm)是一个试点项目,目的是在肯尼亚、乌干达、加纳、尼日尔、尼日利亚、马达加斯加、坦桑尼亚(大陆)和桑给巴尔等八个非洲疟疾流行地区补贴有质量保证的青蒿素类联合疗法。该规划的目标是提高以青蒿素为基础的联合疗法(ACT)的可负担性和可获得性,以及相对于其他效果较差的抗疟疾药物的市场份额。总体而言,AMFm计划对私营营利部门的影响大于公共部门。一般来说,在大多数国家,公共服务的工作不如私营部门好。偏远地区服务不足,需要长途跋涉才能获得资源和护理。一般来说,私营部门能够提供以青蒿素为基础的药物,只要它有利可图。7个国家显示私营部门的可获得性显著增加,6个地区的QAACT成本显著下降,下降幅度从1.28美元到4.82美元不等,所有8个地区的市场份额都有所增加。在偏远地区的影响是巨大的,60%(加纳)和48.5%(肯尼亚)的偏远地区设施储存了QAACTs。与制造商的谈判、私营部门的参与以及支持性干预措施是AMFm成功的关键。随后,AMFm试点项目转变为仅涉及6个国家的私营部门共同支付机制。由于项目成本巨大,潜在原因是不必要和过多的ACTs订单,估计总计5亿美元,AMFm项目无法持续下去。解决这一可持续性问题将使这类项目更适用于其他疟疾流行国家,这些国家的财政资源有限。
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