Synthesis and some pharmacological properties of 1,2-amino ethers with natural monoterpene structures.

A Siemieniuk, H Szałkowska-Pagowska, S Lochyński, K Piatkowski, B Filipek, J Krupińska, R Czarnecki, T Librowski, I Szymańska
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Abstract

Synthesis and physicochemical and pharmacological properties of 10 analogs of 2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethoxy]N, N-diethylamino ethane (3) have been described. The compounds possess toxicity close to or lower than the parent compound--myrtecaine, have no antiarrhythmic activity but some of them (15, 16, 22, 24), similarly as compound 3, show quite strong local anesthetic action.

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具有天然单萜结构的1,2-氨基醚的合成及一些药理性质。
报道了10种2-[2-(6,6-二甲基双环[3.1.1]庚-2-烯-2-基)乙氧基]N, N-二乙基氨基乙烷(3)类似物的合成及其理化药理性质。这些化合物具有接近或低于母体化合物myrtecaine的毒性,没有抗心律失常活性,但其中一些(15,16,22,24)与化合物3类似,表现出相当强的局部麻醉作用。
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