Free Radicals Scavenging Potential Of The Aqueous Extract Of Viscum Album (Mistletoe) Leaves In Diabetic Wistar Rats Hepatocytes

H. Nwanjo
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引用次数: 22

Abstract

The aqueous extract of Viscum album leaf was investigated for its possible hypoglycaemic and antioxidant potentials in streptozotocin (STZ) induced diabetic Wistar rats. A single I.P. injection of STZ at the dose of 65 mg/kg body weight elevated the glucose levels > 205 mg/dl after 3 days. Treatment with the aqueous extract at the dose of 100 mg/kg and 200 mg/kg body weight resulted in significant reduction (P<0.05) in blood glucose levels. Body weights were significantly reduced (P<0.05) in STZ-Induced diabetic rats when compared to normal rats while the extract significantly (P<0.05) prevented a decrease in body weight in the V. album treated diabetic rats. The aqueous extract of the V. album leaf administration also resulted in decreased levels of malondialdehyde (MDA) and increased levels of reduced glutathione (GSH), vitamins C and E and the activities of superoxide dismutase (SOD) and Catalase (CAT) thus resulting in reducing the free radical formation in blood and liver tissues of the diabetic rats. These observations demonstrated that aqueous extract of Viscum album leaf have strong hypoglycaemic effect and in vivo antioxidant activity in STZ-Induced diabetic rats and was dose dependent.
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槲寄生叶水提物对糖尿病大鼠肝细胞自由基清除能力的研究
研究了荆荆叶水提物对链脲佐菌素(STZ)诱导的糖尿病大鼠的降糖和抗氧化作用。单次ig注射STZ,剂量为65 mg/kg体重,3天后血糖水平升高至205mg /dl。以100 mg/kg和200 mg/kg体重的水提物处理大鼠血糖水平显著降低(P<0.05)。与正常大鼠相比,stz诱导的糖尿病大鼠体重明显降低(P<0.05),而提取物对V. album治疗的糖尿病大鼠体重的降低作用显著(P<0.05)。紫苏叶水提物还能降低糖尿病大鼠血液和肝脏组织中丙二醛(MDA)水平,增加还原性谷胱甘肽(GSH)、维生素C和E水平以及超氧化物歧化酶(SOD)和过氧化氢酶(CAT)活性,从而减少自由基的形成。实验结果表明,荆芥叶水提物对stz诱导的糖尿病大鼠具有较强的降血糖作用和体内抗氧化活性,且具有剂量依赖性。
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