Pain Control and Sedation in Neuro Intensive Critical Unit

Soo-Hyun Park, Yerim Kim, Yeojin Kim, J. Bae, Ju-Hun Lee, Wook-Sung Kim, Hong-Ki Song
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Abstract

Neurocritical patients who can self-report pain use the 0-10 numerical rating scale (NRS, verbal or visual form). However, critically ill patients whose nervous systems cannot express pain use the behavioral pain scale (BPS) and the critical care pain observation tool (CPOT) behavioral pain assessment tools. These tools reveal pain-related changes in movement, facial expression, posture, and physiological indicators such as heart rate, blood pressure, and respiratory rate. In pain control, it is first essential to reduce unnecessary painkillers through non-drug therapy and maximize the effect of the administered analgesics. For nonneuropathic pain, narcotic analgesics such as fentanyl, hydromorphone, morphine, and remifentanil are administered intravenously. Gabapentin, pregabalin, and carbamazepine are recommended along with narcotic analgesics for neuropathic pain control. In addition, nonnarcotic analgesics for multi-modal analgesia are used to reduce the use of narcotic analgesics or the side effects of narcotic analgesics. In the intensive care unit (ICU), the sedation-agitation scale (SAS) and the Richmond agitation-sedation scale (RASS) are used to determine the depth of sedation to be maintained during shallow or deep sedation, considering the condition of the critically ill patient. When selecting sedatives for critically ill patients, preferentially consider nonbenzodiazepines such as propofol or dexmedetomidine rather than benzodiazepines such as midazolam or lorazepam. In addition, patients use painkillers or sedatives for over a week, and neurological changes or physiological dependence may occur. Therefore, clinicians should evaluate the critically ill patient’s condition, and sedatives and painkillers should be reduced or discontinued.
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神经重症病房的疼痛控制与镇静
能够自我报告疼痛的神经危重症患者使用0-10数值评定量表(NRS,口头或视觉形式)。而神经系统不能表达疼痛的危重患者则使用行为疼痛量表(behavioral pain scale, BPS)和重症疼痛观察工具(critical care pain observation tool, CPOT)行为疼痛评估工具。这些工具揭示了运动、面部表情、姿势以及心率、血压和呼吸频率等生理指标与疼痛相关的变化。在疼痛控制中,首先必须通过非药物治疗减少不必要的止痛药,并最大限度地发挥镇痛药的作用。对于非神经性疼痛,麻醉性镇痛药如芬太尼、氢吗啡酮、吗啡和瑞芬太尼可静脉注射。加巴喷丁、普瑞巴林和卡马西平建议与麻醉性镇痛药一起用于神经性疼痛控制。此外,采用非麻醉性镇痛药进行多模态镇痛,以减少麻醉性镇痛药的使用或麻醉性镇痛药的副作用。在重症监护室(ICU),考虑到危重患者的情况,采用镇静-躁动量表(SAS)和Richmond躁动-镇静量表(RASS)来确定浅镇静或深镇静期间维持的镇静深度。在为危重病人选择镇静剂时,优先考虑非苯二氮卓类药物,如异丙酚或右美托咪定,而不是苯二氮卓类药物,如咪达唑仑或劳拉西泮。此外,患者使用止痛药或镇静剂超过一周,可能出现神经变化或生理依赖。因此,临床医生应评估危重患者的病情,并应减少或停用镇静剂和止痛药。
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