Understanding of Glucocorticoid Induced Osteoporosis

Abstract

Glucocorticoids are effective for many inflammatory diseases, but long-term use can lead to osteoporosis and resulting fractures. An initial evaluation of fracture risk should be done within six months of starting glucocorticoid use, and fracture risk should be evaluated every 12 months after long-term use. Adequate calcium and vitamin D administration are required when taking 2.5 mg prednisolone daily for more than three months. Bisphosphonates, teriparatide, and denosumab can be used when there is a moderate or higher fracture risk due to glucocorticoid-induced osteoporosis.