Gama-glutamil trasferasa en suero, adyuvante del antígeno prostático específico en el diagnóstico del cáncer de próstata

Q4 Medicine Revista mexicana de urologia Pub Date : 2015-11-01 DOI:10.1016/j.uromx.2015.08.004

M. Díaz-Pérez , M.A. Hernández-Manzanares , V. Montes-Martínez , E.A. Sánchez-Valdivieso

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引用次数: 1

Abstract

Objective

The aim of this study was to determine the relation of prostate-specific antigen to histopathologic and biochemical indicators in patients with a clinical prostate cancer diagnosis.

Material and methods

A cross-sectional study was conducted on patients 50 years and older that had a clinical diagnosis of prostate cancer within the time frame of March 2012 and August 2014. Prostate-specific antigen levels and histopathologic and biochemical data were analyzed through descriptive statistics, the Spearman correlation, ROC curves, and contingency tables.

Results

The median age of the patients was 71 years and the median prostate-specific antigen value was 8.1 ng/ml (2 ng/ml to 3,685 ng/ml). Pathologic study confirmed prostate cancer diagnosis in 50 patients. There was an association between prostate-specific antigen levels and Gleason score (p < 0.05), as well as between prostate-specific antigen and gamma-glutamyl transferase (p < 0.05).

Conclusions

Gamma-glutamyl transferase determination is suggested for increasing prostate-specific antigen sensitivity and specificity. The number of patients was a limitation of our study.

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血清-谷氨酰胺转移酶，前列腺特异性抗原佐剂在前列腺癌诊断中的作用

目的探讨前列腺特异性抗原与临床诊断前列腺癌患者组织病理及生化指标的关系。材料与方法对2012年3月至2014年8月期间50岁及以上临床诊断为前列腺癌的患者进行横断面研究。通过描述性统计、Spearman相关、ROC曲线和列联表分析前列腺特异性抗原水平和组织病理生化数据。结果患者年龄中位数为71岁，前列腺特异性抗原中位数为8.1 ng/ml (2 ~ 3685 ng/ml)。病理研究证实了50例患者的前列腺癌诊断。前列腺特异性抗原水平与Gleason评分之间存在相关性(p <0.05)，前列腺特异性抗原与γ -谷氨酰转移酶之间(p <0.05)。结论-谷氨酰转移酶检测可提高前列腺特异性抗原的敏感性和特异性。患者的数量是我们研究的一个限制。

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来源期刊

Revista mexicana de urologia Medicine-Urology

CiteScore

0.20

自引率

0.00%

发文量

期刊介绍： Revista Mexicana de Urología (RMU) [Mexican Journal of Urology] (ISSN: 0185-4542 / ISSN electronic: 2007-4085) is bimonthly publication that disseminates research by academicians and professionals of the international medical community interested in urological subjects, in the format of original articles, clinical cases, review articles brief communications and letters to the editor. Owing to its nature, it is publication with international scope that disseminates contributions in Spanish and English that are rigorously reviewed by peers under the double blind modality. Neither journalistic documents nor those that lack rigorous medical or scientific support are suitable for publication.