Clinical Characterization of Hepatitis A Infection Complicated with Acute Kidney Injury and Sequence Analysis of the VP1 Region

Abstract

was independently associated with AKI occurrence in non-fulminant HAV infections (odds ratios=1.094, 95% confidence interval=1.011−1.183). HAV RNA was detected in 57 (86.4%) patients: 53 strains (93.0%) showed genotype IIIA and 4 strains pre- sented genotype IA. All HAV isolates from the AKI patients belonged to the genotype IIIA and shared the identical sequences with those from the non-AKI patients. Conclusion: This study indicates that higher level of C-reactive protein is associated with AKI occurrence in non-fulminant HAV infections. There were no spe- cific nucleotide or amino acid substitutions in the VP1 region associated with AKI occurrence. (Korean J Clin Microbiol 2010;13:7-13)