Epidemiological and clinical implications in Kidney Transplantation of occult Hepatitis C virus infection

T. Olea, I. Castillo, C. Jiménez, J. Díez, J. Bartolomé, M. Santana, M. López-Oliva, E. González, R. Selgas, Carreño
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Abstract

Occult Hepatitis C virus (HCV) infection (OCI) is characterized by the presence of HCV-RNA in liver or in peripheral blood mononuclear cells (PBMC) in the absence of serological markers. HCV infection in kidney transplant (KT) recipients is associated with lower patient and graft survival. However, the relationship between KT outcome and OCI is unknown. Our aim was to determine in KT recipients the prevalence, risk factors for OCI, and its prognostic implications. We tested 149 adults KT recipients for the presence of OCI.
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隐匿性丙型肝炎病毒感染肾移植的流行病学及临床意义
隐匿性丙型肝炎病毒(HCV)感染(OCI)的特点是在没有血清学标志物的情况下,肝脏或外周血单核细胞(PBMC)中存在HCV- rna。肾移植(KT)受者的HCV感染与较低的患者和移植物存活率相关。然而,KT结果与OCI之间的关系尚不清楚。我们的目的是确定KT受体OCI的患病率、危险因素及其预后意义。我们测试了149名成人KT接受者是否存在OCI。
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