HBA1C SEBAGAI KANDIDAT BIOMARKER UNTUK PREDIKSI PROGESIVITAS GANGGUAN KOGNITIF TERKAIT DIABETES MELITUS TIPE 2

Putri Nurhayati, Achmad Mujahidin Irham, I. G. B. Pramana, Herpan Syafii Harahap
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引用次数: 1

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia which underlie its complications, including cognitive impairment. T2dm-associated cognitive impairment is generally characterized by the decrease in at least one cognitive domain. However, its progression can be slowed by appropriate blood glucose control. Hb1Ac is a candidate of appropriate biomarker in predicting the progression of T2DM-associated cognitive impairment. This is based on several important characteristics it has, including a good blood glucose index, low daily biological variability, relatively unaffected by stress conditions, and unaffected by variations due to loading the amount of glucose.
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HBA1C是2型糖尿病相关认知功能障碍的候选者
2型糖尿病(T2DM)是一种以胰岛素抵抗和高血糖为特征的慢性代谢紊乱,其并发症包括认知障碍。t2dm相关的认知障碍通常以至少一个认知领域的下降为特征。然而,通过适当的血糖控制可以减缓其进展。Hb1Ac是预测t2dm相关认知障碍进展的合适生物标志物。这是基于它的几个重要特征,包括良好的血糖指数,低的日常生物变异性,相对不受应激条件的影响,不受葡萄糖负荷变化的影响。
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