Analysis of results determination of level of vascular endothelial growth factor, receptor for vascular endothelial growth factor and big endotelin-1 in structure of arteriovenous malformations

I. Altman
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Abstract

Objective ‒ to assess the diagnostic significance of angiogenesis factors based on the study of the level of angiogenesis factors (vascular endothelial growth factor (VEGF-A), specific receptor for vascular endothelial growth factor (VEGFR-1), endothelial inflammation factor (Big Endothelin-1)) in arterial and venous blood of patients with arteriovenous malformations (AVM) and healthy individuals without AVM. Materials and methods. In 2019–2021 a study according to the data of enzyme-linked immunosorbent assay the level of VEGF-A, VEGFR-1 and Big Endothelin-1 in the plasma of arterial and venous blood of 50 (19 (38.0 %) men and 31 (62.0 % women)) with AVM of different localization was carried out. The age of patients ranged from 3 to 51 years, the mean age ‒ (27.79 ± 2.19) years. The control group consisted of 35 healthy individuals (20 men and 15 women) without AVM. Patients with AVMs were divided into two groups: with small and medium-sized AVM in the stage of compensation (n=32) and with large and giant AVM in the stage of subcompensation or decompensation (n=18). Results. A significant (p < 0.05) difference was proved between the concentration of VEGF-A, VEGFR-1, Big Endothelin-1 in the plasma of arterial and venous blood of patients with AVM. This fact proves that the processes of pathological angiogenesis occur precisely in the structure of AVM. The value of VEGF-A, VEGFR-1 and BE-1 in patients with small and medium AVM was higher than in healthy individuals. The VEGF-A level was significantly (p < 0.05) in 2.4 times higher than in the control group, the VEGFR-1 level ‒ in 1.4 times, and the ET-1 level ‒ in 1.5 times. The value of VEGF-A, VEGFR-1 and BE-1 level in patients with large and giant AVM was significantly (p < 0.05) higher than in healthy individuals: VEGF-A ‒ in 7.2 times, VEGFR-1 ‒ in 2.36 times, and BE-1 ‒ in 1.7 times. Conclusions. The data obtained make it possible to statistically reliably state that the processes of pathological angiogenesis occur directly in the structure of AVM. A statistically significant dependence of the level of VEGF-A, VEGFR-1 and BE-1 in the blood plasma of patients on the size of the AVM and the stage of its compensation was revealed.
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动静脉畸形组织中血管内皮生长因子、血管内皮生长因子受体及大内皮素-1水平的测定结果分析
目的——通过研究动静脉畸形(AVM)患者和非AVM健康人动脉和静脉血中血管生成因子(血管内皮生长因子(VEGF-A)、血管内皮生长因子特异性受体(VEGFR-1)、内皮炎症因子(大内皮素-1)水平,评价血管生成因子的诊断意义。材料和方法。2019-2021年,根据酶联免疫吸附试验数据,对50例(男性19例(38.0%),女性31例(62.0%))不同部位AVM患者动脉和静脉血浆VEGF-A、VEGFR-1和大内皮素-1水平进行了研究。患者年龄3 ~ 51岁,平均年龄-(27.79±2.19)岁。对照组为35名无AVM的健康个体(20名男性,15名女性)。将AVM患者分为两组:处于代偿期的中小型AVM患者(n=32)和处于亚代偿或失代偿期的大型AVM患者(n=18)。结果。AVM患者动、静脉血血浆VEGF-A、VEGFR-1、大内皮素-1浓度差异有统计学意义(p < 0.05)。这一事实证明病理性血管生成过程恰好发生在AVM的结构中。中小AVM患者VEGF-A、VEGFR-1和BE-1均高于健康人。VEGF-A水平是对照组的2.4倍,VEGFR-1水平是对照组的1.4倍,ET-1水平是对照组的1.5倍,差异有统计学意义(p < 0.05)。大、巨型AVM患者VEGF-A、VEGFR-1、BE-1水平显著高于健康人(p < 0.05): VEGF-A -是健康人的7.2倍,vegfr - 2.36倍,BE-1 - 1.7倍。结论。所获得的数据可以统计可靠地说明病理性血管生成过程直接发生在AVM结构中。患者血浆中VEGF-A、VEGFR-1和BE-1水平与AVM大小及其代偿阶段有统计学意义。
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