68GaTHM2BED: a potential generator-produced tracer of myocardial perfusion for positron emission tomography

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology Pub Date : 1992-05-01 DOI:10.1016/0883-2897(92)90158-U

Susan L Madsen , Michael J Welch , Ramunas J Motekaitis , Arthur E Martell

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引用次数: 7

Abstract

THM₂BED [N,N,N′,N′-tetrakis-(2-hydroxy-3,5-dimethylbenzyl)ethylenediamine] is a new hexadentate ligand which has been synthesized and complexed with gallium isotopes. A conditional stability constant of 22.3 and a pM value of 20.7 have been determined for GaTHM₂BED at physiological pH. Hexachelated and pentachelated complexes of GaTHM₂BED have been isolated via preparatory HPLC and evaluated individually. The hexachelated isomer of ⁶⁸GaTHM₂BED clears slowly from the myocardium of rats and at 1 h post-injection the heart-to-blood ratio is 1.65. The data ratio indicates that this radiotracer may be capable of measuring blood flow in the heart. The ability of ⁶⁸GaTHM₂BED to delineate myocardial tissue in a dog has been evaluated and good images were obtained using hexachelated ⁶⁸GaTHM₂BED. There is evidence that this complex penetrates the blood-brain barrier.

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68GaTHM2BED:一种潜在的心肌灌注示踪剂，用于正电子发射断层扫描

THM2BED [N,N,N '，N ' -四基-(2-羟基-3,5-二甲基苄基)乙二胺]是一种新的六齿配体，已合成并与镓同位素络合。经测定，GaTHM2BED在生理ph值下的条件稳定常数为22.3,pM值为20.7。通过预备HPLC分离出GaTHM2BED的六价和五价配合物，并分别进行了评价。68GaTHM2BED的六化异构体从大鼠心肌中缓慢清除，注射后1 h心血比为1.65。数据比率表明，这种放射性示踪剂可能能够测量心脏的血流。68GaTHM2BED对狗心肌组织的描画能力进行了评估，使用hexachelated 68GaTHM2BED获得了良好的图像。有证据表明这种复合物能穿透血脑屏障。

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International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

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