Visualization of RNA secondary structure with pseudoknots

Lina Yang, Yang Liu, Huiwu Luo, Xichun Li, Y. Tang
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Abstract

The function of pseudoknots cannot be ignored in the RNA secondary structure. Existing methods for analyzing RNA secondary structures with pseudoknots exhibit many shortcomings. This paper presents a novel RNA secondary structure visualization method in the case of a joint analysis of RNA primary structures and secondary structures. The way is based on the page number representation of the RNA secondary structure. It innovatively uses five vectors to represent bases, which are sequentially connected to outline the characteristics of the RNA secondary structure. The method covers almost all the constituent elements of the RNA secondary structure and extracts features completely. Experiments are based on the available techniques for large-scale annotation of RNA secondary structures, using a combination method of discrete wavelet transform and fractal dimension. The classification effect is compared with the previous RNA secondary structure representation methods. Experimental results show that the RNA secondary structure visualization method proposed in this paper has good application prospects in RNA secondary structure classification.
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带假结的RNA二级结构的可视化
假结在RNA二级结构中的作用不容忽视。现有的分析具有假结的RNA二级结构的方法存在许多缺陷。本文提出了一种结合RNA一级结构和二级结构分析的新型RNA二级结构可视化方法。这种方法是基于RNA二级结构的页码表示。它创新地使用五个载体来表示碱基,这些碱基依次连接以勾勒出RNA二级结构的特征。该方法几乎涵盖了RNA二级结构的所有组成元素,并完整地提取了特征。实验基于现有的RNA二级结构大规模标注技术,采用离散小波变换和分形维数相结合的方法。并与已有的RNA二级结构表示方法进行了分类效果比较。实验结果表明,本文提出的RNA二级结构可视化方法在RNA二级结构分类中具有良好的应用前景。
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