{"title":"Modeling studies of cellular response to ultrashort, high-intensity electric fields","authors":"R. Joshi, Q. Hu, K. Schoenbach, V. Lakdawala","doi":"10.1109/CEIDP.2003.1254867","DOIUrl":null,"url":null,"abstract":"The dynamics of electroporation in biological cells subjected to nanosecond, high intensity pulses are studied based on a coupled scheme involving current continuity and Smoluchowski equations. A new distributed current model is presented for potential distribution to includes dynamic conductivities of cell membranes and substructures caused by pore formation. Different cell responses of normal and malignant (Farage) tonsillar B-cells are compared and discussed. It is shown that ultrashort, high-intensity electric pulses could selectively damage cancer cells.","PeriodicalId":306575,"journal":{"name":"2003 Annual Report Conference on Electrical Insulation and Dielectric Phenomena","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2003-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2003 Annual Report Conference on Electrical Insulation and Dielectric Phenomena","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/CEIDP.2003.1254867","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14
Abstract
The dynamics of electroporation in biological cells subjected to nanosecond, high intensity pulses are studied based on a coupled scheme involving current continuity and Smoluchowski equations. A new distributed current model is presented for potential distribution to includes dynamic conductivities of cell membranes and substructures caused by pore formation. Different cell responses of normal and malignant (Farage) tonsillar B-cells are compared and discussed. It is shown that ultrashort, high-intensity electric pulses could selectively damage cancer cells.
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