Is There a CYP1A1 in Marine Bivalves? Expressed Sequences Related to Cytochrome P450 in Crassostrea Rhizophorae

M. Rebelo, J. Moreira, M. Moraes, D. Coutinho, J. Torres
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引用次数: 11

Abstract

The successful use of CYP1A1 as a biomarker of exposure to polynuclear aromatic hydrocarbon in vertebrates lead to a chase for it in marine bivalves. Nevertheless, published results are mostly inconclusive, even with molecular approaches, and there is no clear evidence of a bivalve CYP1A1. Phylogeny of P450 suggests that bivalves could have evolved their own CYP enzymes. Apparently, they even lack the AhR pathway. New sequences from the oyster Crassostrea rhizophorae exhibited little homology to known CYP1A1 but revealed a new CYP2-like gene. Finally, the low activity of the P450 system could be explained by alternative detoxification mechanisms such as the highly active MDR system.
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海洋双壳类动物中是否存在CYP1A1 ?细胞色素P450相关序列的表达
在脊椎动物中,CYP1A1作为多核芳香烃暴露的生物标志物的成功应用导致了海洋双壳类动物对其的追逐。然而,即使采用分子方法,已发表的结果也大多是不确定的,并且没有明确的证据表明存在双壳类CYP1A1。P450的系统发育表明双壳类动物可能进化出了自己的CYP酶。显然,它们甚至缺乏AhR通路。来自牡蛎的新序列与已知的CYP1A1几乎没有同源性,但发现了一个新的cyp2样基因。最后,P450系统的低活性可以用其他解毒机制(如高活性的MDR系统)来解释。
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