Chemotherapy-Induced Palmo-Plantar Erythrodysesthesia and Leukonychia Striata in a Systemic Lupus Erythematosus Patient

Abstract

1. Case Report A 58-years-old female suffering from systemic lupus erythematosus (SLE) since 2018 underwent induction chemotherapy for acute myeloid leukaemia (AML). The diagnosis of SLE was based on: photosensitivity, malar rash, arthritis of the hands, positive antinuclear and Ro (SSA) antibodies. She was on remission receiving no medications. The treatment protocol of AML consisted of intravenous infusion of cytarabine plus daunorubicine. The patient, on day 11 developed erythematosus plaques on the dorsal and palmar surfaces of the hands, as well as a bullous skin lesion on the middle phalanx of the third finger on the left hand (Figure 1A: upper insert photo) and transverse white lines on the nails (Figure 1A: lower insert photo). An Immunological work-up was ordered to ruleout a flare-up of SLE which was unremarkable.