Thrombocytopenia and Thrombocytopathy

Abstract

Platelet disorders are quantitative or qualitative, or both. Either markedly increased or decreased numbers of platelets can cause harmful sequelae. Platelet disorders can be divided into acquired or hereditary; acquired disorders are much more common than congenital disorders. Platelet disorders can be due to increased platelet destruction or decreased platelet production. Pseudothrombocytopenia, dilutional effects, or possible splenic sequestration should be considered when the platelet count is low for the first time. The recent addition of a drug, commonly used in intensive care units, is also an important consideration for patients with newly acquired thrombocytopenia.