EXOSOME’ EMERGING FUNCTION IN CARCINOGENESIS AND CANCER CHEMOTHERAPY RESISTANCE

Era's Journal of Medical Research Pub Date : 2023-06-01 DOI:10.24041/ejmr2023.18

Raushan Kumar, Sharique Ahmad

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Abstract

Globally, cancer and related disorders are major health issues. The scientific community has many obstacles in tackling this problem and creating a streamlined therapy and drug administration plan. Chemotherapy is necessary for cancer treatment, however many individuals acquire drug resistance due to recurrent medication delivery. Chemotherapy resistance hinders cancer treatment. Exosomes are vesicles their size range from 40 to 160 nm (the average being 100 nm). Exosomes can include DNA, RNA, fatty acid, metabolites as well cytosol, and cell surface proteins. Since exosome formation's physiological purpose is unknown, more research is needed. Exosomes regulate intercellular communication and help cancer cells develop chemoresistance. Exosomes can reveal physiological and pathological information about their parent cells. Liquid biopsies assess cancer chemosensitivity using exosomes. Because exosomes are stable and sensitive. This review covers exosome-mediated cancer chemoresistance. We also studied tumor-related processes, exosome biogenesis, and their current and potential roles in cancer diagnosis and treatment, drug delivery systems, and chemoresistance.

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Era's Journal of Medical Research

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