Lidocaine as an adjunct to hyperbaric therapy in decompression illness: a case report.

Undersea biomedical research Pub Date : 1992-05-01
A Drewry, D F Gorman
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Abstract

A recreational scuba diver with nervous system decompression illness had a poor response to hyperbaric therapy. On the basis of available and supportive in vivo data, he was then given a continuous infusion of lidocaine (serum levels, low therapeutic range: 6.4-9.1 mumol/liter). Within 24 h of the start of this infusion he experienced a full resolution of his neurologic deficits. His symptoms recurred 3 days later, but again completely resolved after further hyperbaric therapy and concurrent administration of lidocaine (serum levels: 6.9-9.1 mumol/liter). This observation supports the need to conduct trials of lidocaine as an adjunct to hyperbaric therapy in decompression illness.

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利多卡因辅助高压氧治疗减压病1例报告。
一位患有神经系统减压疾病的休闲潜水者对高压氧治疗反应不佳。根据现有的和支持性的体内数据,他被连续输注利多卡因(血清水平,低治疗范围:6.4-9.1 μ mol/l)。在开始注射后的24小时内,他的神经功能缺陷得到了完全的解决。3天后症状再次出现,但在进一步高压氧治疗和同时给予利多卡因(血清水平:6.9-9.1 μ mol/l)后再次完全缓解。这一观察结果支持了将利多卡因作为减压疾病高压氧治疗的辅助疗法进行试验的必要性。
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Description and evaluation of a simple method for microbiological studies on otitis externa. The Americans with Disabilities Act and the injured diver. Saturation decompression schedules based on a critical tissue supersaturation criterion. Effects of an increased PO2 during recompression therapy for the treatment of experimental cerebral arterial gas embolism. Effects of hyperoxia on human endothelial cell proliferation and morphology in vitro.
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