R. Toche, Bhausaheb K. Ghotekar, M. A. Kazi, Shivaraj P. Patil, M. Jachak
{"title":"New Approach for the Synthesis of Pyrido[1,2-a]pyrimidines","authors":"R. Toche, Bhausaheb K. Ghotekar, M. A. Kazi, Shivaraj P. Patil, M. Jachak","doi":"10.3814/2008/434329","DOIUrl":null,"url":null,"abstract":"A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α -acetyl- γ -butyrolactone, which upon cyclization using phosphorus \n oxychloride or ethanol in sodium ethoxide furnished the pyrido[1,2-a]pyrimidines in good yield.","PeriodicalId":169134,"journal":{"name":"Scholarly Research Exchange","volume":"4 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2008-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scholarly Research Exchange","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3814/2008/434329","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α -acetyl- γ -butyrolactone, which upon cyclization using phosphorus
oxychloride or ethanol in sodium ethoxide furnished the pyrido[1,2-a]pyrimidines in good yield.
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