[Prenatal risk factors and the status of local defense of the intestines in premature newborn infants].

Abstract

A randomized study was made to examine certain characteristics of local immunity of the intestine (immunoglobulins in coprofiltrates, microbiocenosis) and the immunoglobulin composition of the milk of mothers to 108 premature breast-fed children of the first month of life. It has been established that toward the end of the second week of life, there was a remarkable decrease in the characteristics of secretory IgA (SIgA) in coprofiltrates of the newborn whose mothers suffered from gestosis (group 2) and in children born to mothers with infectious pathology (group 3) as compared to conventionally healthy premature children (group 1). The group 3 neonates showed a significantly less amount of IgG. According to the examinations made over time, the deficiency of secretory antibodies rose in group 2, declined in group 3, whereas the group 1 children manifested an increase in SIgA. The group 2 and 3 children demonstrated more profound dysbiotic disturbances, characterized by long persistence of opportunistic microorganisms and by the appearance in some cases of pathogenic microorganisms in the intestine. All this requires distinguishing risk groups and carrying out additional preventive and treatment measures in such children.