Association of ABO and Rh Blood Groups with Helicobacter pylori Seropositivity in Gonabad City, Iran: A Case-Control Study

Abstract

Background: Helicobacter pylori infection is one of the most common chronic bacterial infections in humans, affecting large populations worldwide. Objectives: The aim of this study was to investigate the relationship between H. pylori infection prevalence with ABO and Rh blood groups. Methods: This descriptive-analytical study was conducted with a case-control design on individuals with anti-H. pylori positive test. Patients with IgG pylori were included in the study based on the inclusion criteria. The individuals were divided into two groups based on antibody titer. The case group included subjects with positive serological results with a titer greater than 12 u/mL IgG, and the control group entailed subjects with negative serological results with a titer less than 8 u/mL IgG. The ABO and Rh blood groups of both groups were examined based on case information. Finally, the data were entered into the SPSS software, and a significance level of 5% was considered for all analyses. Results: According to the results of this study, there was no significant relationship between the blood group and H. pylori infection (P > 0.05). However, the prevalence of blood type A was significantly higher in individuals with positive H. pylori IgG test. Conclusions: The current study suggests no association between ABO and Rh groups, but people with A blood group infected with H. pylori need more attention.