A. Rasulov, J. Madyarov, A. E. Kulikov, Z. Rasulov, L. A. Shestakova, D. Chekini, E. K. Ibragimov, E. Puchkova, Yu. E. Lvova, R. A. Rasulov
{"title":"Neoadjuvant immunotherapy in treatment of oligometastatic locally advanced colon cancer. Clinical case","authors":"A. Rasulov, J. Madyarov, A. E. Kulikov, Z. Rasulov, L. A. Shestakova, D. Chekini, E. K. Ibragimov, E. Puchkova, Yu. E. Lvova, R. A. Rasulov","doi":"10.17650/2782-3202-2022-2-3-21-27","DOIUrl":null,"url":null,"abstract":"Immunotherapy has improved the results of treatment of patients with metastatic colorectal cancer. According to literature, the most cancericidal effect revealed in a microsatellite instability high (MSI-H) tumors. In our case, PD-1/PD-L1/PD-L2 inhibitors (nivolumab) treatment for locally advanced MSI-H colon carcinoma with liver metastasis in 44-year-old patient resulted in tumor regression, so that R0 surgical procedure became possible. Computed tomography scan and pathology report showed complete response, in primary and metastatic tumors. As a result, this allowed to improve the quality of patient’s life.","PeriodicalId":318498,"journal":{"name":"MD-Onco","volume":"5 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"MD-Onco","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17650/2782-3202-2022-2-3-21-27","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Immunotherapy has improved the results of treatment of patients with metastatic colorectal cancer. According to literature, the most cancericidal effect revealed in a microsatellite instability high (MSI-H) tumors. In our case, PD-1/PD-L1/PD-L2 inhibitors (nivolumab) treatment for locally advanced MSI-H colon carcinoma with liver metastasis in 44-year-old patient resulted in tumor regression, so that R0 surgical procedure became possible. Computed tomography scan and pathology report showed complete response, in primary and metastatic tumors. As a result, this allowed to improve the quality of patient’s life.
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