Determination of Cell Stiffness Using Polymer Microbeads as Reference

Sevde Omeroglu, Rahmetullah Varol, Z. Karavelioglu, Aslıhan Karadağ, Y. Başbınar, Muhammed Enes ORUC, H. Uvet
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Abstract

Knowing the mechanical properties of cells is very important in cell detection, analysis of cell activities, diagnosis and drug treatment. The determination of cell stiffness, which used effectively in cell analysis, is carried out with different measurement techniques. In this study, the stiffness of cells is determined by comparison to the displacement of polystyrene microparticles induced by vibration generated by piezoelectric transducers. The difference of stiffness of the cells and polystyrene microparticles is measured using a digital holographic imaging technique.
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以聚合物微珠为基准测定细胞刚度
了解细胞的力学性质在细胞检测、细胞活性分析、诊断和药物治疗中具有重要意义。在细胞分析中有效使用的细胞刚度的测定采用不同的测量技术进行。在这项研究中,通过比较由压电换能器产生的振动引起的聚苯乙烯微粒的位移来确定细胞的刚度。采用数字全息成像技术测量了聚苯乙烯微粒子与细胞的刚度差。
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