Fundamental Study of Cannabidiol Effect on MCF-7 with Low Voltage Pulse Electric Field

Abstract

In various cancer types, plant extract has been found to be an important and useful preventive agent for chemotherapy. Cannabidiol is one of the interesting plants that has recently been identified as a possible anti-cancer agent. The inhibition of cancer cells and the activation of cancer cell death or apoptosis are the major effects of cannabinoids on tumours. Latest studies have shown that cannabidiol decreases the viability of cells in multiple cancer cell types, such as leukemia, colorectal, breast cancer, lung, and prostate cancer. The pulse electric fields were known to affect the opening of pores on the cell membrane effectively. It has also been used as one of today’s cancer treatment techniques in clinical practice. Both of these approaches can be combined. For the cancer treatment procedure, it could increase further reduction in time taken and less harmful / after side effects for cancer patients. The pulse electric field range most widely used is 100-1000 V/cm. Cannabidiol inhibitory concentration (IC50) for breast cancer cells will be estimated for this study. The efficacy of this mechanism can be determined by controlling cell proliferation, viability, and anti-proliferation by cancer cells. These approaches could be an effective way to treat cancer without affecting or leaving cancer patients with any side effects.