Relation between anti-thyroid peroxidase antibody and recurrent pregnancy loss: A case control study

Abstract

Background: Thyroid dysfunction and autoimmunity are relatively common clinical scenario in women within reproductive age group and have been correlated and linked to a spectrum of adverse pregnancy outcomes such as recurrent miscarriage.  Aim: To investigate the correlation and linkage between anti-TPO antibody and recurrent miscarriage.Materials and Methods: This case control observational research study was conducted on 90 pregnant female out which 45 with history of recurrent miscarriage were cases and 45 without such history were controls.Results: The mean age of control group was 25.29 while it was 26.69 in cases group. The prevalence of anti-tpo antibody positivity in the study group was 18.8%.out of 90 pregnant female ;17 were positive for anti-tpo antibody. The prevalence of thyroid autoimmunity in pregnant women with recurrent abortion was (37.8%) while it was (0%) in the healthy group (P=0.0).  Conclusion:There was significant relationship between anti thyroid antibody positivity and recurrent miscarriage. Thyroid autoimmunity can be considered as risk marker for recurrent miscarriage.