A robust data scaling algorithm for gene expression classification

Abstract

Gene expression data are widely used in classification tasks for medical diagnosis. Data scaling is recommended and helpful for learning the classification models. In this study, we propose a data scaling algorithm to transform the data uniformly to an appropriate interval by learning a generalized logistic function to fit the empirical cumulative density function of the data. The proposed algorithm is robust to outliers, and experimental results show that models learned using data scaled by the proposed algorithm generally outperform the ones using min-max mapping and z-score which are currently the most commonly used data scaling algorithms.