Nucleotides as cotransmitters in vascular sympathetic neuroeffector transmission.

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158839
K Starke, I von Kügelgen, J M Bulloch, P Illes
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引用次数: 13

Abstract

Postganglionic sympathetic cotransmission by noradrenaline (NA) and adenosine 5'-triphosphate (ATP) was studied in isolated arteries from rabbits using as tools alpha-adrenoceptor antagonists and alpha, beta-methylene-ATP which first activates and then desensitizes purine P2X receptors. In the pulmonary artery, NA was the only chemical signal responsible for neurogenic vasoconstriction. In sharp contrast, ATP was the only signal eliciting electric as well as mechanical postjunctional responses in small jejunal arteries. Mixed adrenergic and purinergic transmission was found in the largest ramus caecalis of the ileocolic artery. The purinergic component prevailed in short pulse trains and early in long trains, whereas the adrenergic component prevailed in the late phases of long (20 s) trains. Prejunctional alpha 2-adrenergic autoinhibition markedly depressed purinergic as well as adrenergic transmission as soon as a latency of about 2 s was exceeded.

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核苷酸在血管交感神经效应器传递中的共递质作用。
以α -肾上腺素受体拮抗剂和α, β -亚甲基ATP为工具,研究了兔离体动脉中去甲肾上腺素(NA)和腺苷5′-三磷酸(ATP)在节后交感神经传导中的作用。α -肾上腺素受体拮抗剂先激活嘌呤P2X受体,然后使其脱敏。在肺动脉中,NA是唯一负责神经源性血管收缩的化学信号。与之形成鲜明对比的是,在空肠小动脉中,ATP是唯一引起电反应和机械反应的信号。回结肠动脉最大盲肠支存在肾上腺素能和嘌呤能混合传递。嘌呤能成分在短脉冲和长脉冲早期占优势,而肾上腺素能成分在长脉冲(20 s)后期占优势。当潜伏期超过2 s左右时,交界性α 2-肾上腺素能自抑制可显著抑制嘌呤能和肾上腺素能的传递。
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