A Double Blind, Randomized, Placebo-Controlled Clinical Study of the Nutraceutical Ashwagandha in the Form of Vedaan Ashwagandha KSM 66 Capsules as an Antioxidant, Energy Booster, Nervine Tonic, Anti-Stress and Aphrodisiac in General and Specific Chronic Ailments
{"title":"A Double Blind, Randomized, Placebo-Controlled Clinical Study of the Nutraceutical Ashwagandha in the Form of Vedaan Ashwagandha KSM 66 Capsules as an Antioxidant, Energy Booster, Nervine Tonic, Anti-Stress and Aphrodisiac in General and Specific Chronic Ailments","authors":"Dr. Ravi Raj, D. Kumar, Dr. Ameed Murad","doi":"10.37648/ijrmst.v14i01.013","DOIUrl":null,"url":null,"abstract":"In the modern world, numerous ailments like Tuberculosis and Diabetes Mellitus are common health problems. They can generate a loss of energy in the body, and develop neuropathies which can further generate stress, insomnia, loss of libido and early ageing. In this modem era, stress can disturb an individual’s normal physical and mental health. It causes the perturbation of the body's homeostasis and leads to various physical and psychological health problems. The state of accumulated stress can increase the risk of both acute and chronic psychosomatic illness and weaken immune system of the body. Stress can cause many things such as headaches, anorexia, insomnia, fatigue, or diseases such as hypertension, diabetes mellitus etc. Withania Somnifera is commonly known as Ashwagandha in Ayurvedic medicine, Indian ginseng, poison gooseberry or winter cherry. Well-known antioxidant or Rasayana drug has been chosen and selected for the management of chronic ailments like Tuberculosis and Diabetes mellitus associated with stress, anxiety, headache, insomnia, loss of energy, fatigue, loss of libido. It is used as an antioxidant, diuretic, sedative, anti-inflammatory and aphrodisiac for many ages. Many studies have shown that Withania Somnifera roots have several effects on the central nervous system, including modulation of acetylcholinesterase activity and serotonin receptors, as well as GABA activity (NPD, 2017). Ahmad et al. (2010) described a significant increase (P < 0.01) in sperm concentration and motility in men with normozoospermia, oligozoospermia, and azoospermia treated with Ashwagandha root extract. Results showed a decrease in seminal LPO levels, stress and serum cortisol levels, ROS production, elevated antioxidant levels and overall improvement in sperm quality (concentration and motility), testosterone and LH levels. The current study evaluates the efficacy of Ashwagandha as an antioxidant. Ashwagandha (Withania Somnifera) is already been clinically tried as an adjuvant in the patient with Tuberculosis and Diabetes mellitus. We have given Vedaan Ashwagandha, KSM 66 capsules in our OPD and IPD.","PeriodicalId":178707,"journal":{"name":"International Journal of Research in Medical Sciences and Technology","volume":"89 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Research in Medical Sciences and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37648/ijrmst.v14i01.013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In the modern world, numerous ailments like Tuberculosis and Diabetes Mellitus are common health problems. They can generate a loss of energy in the body, and develop neuropathies which can further generate stress, insomnia, loss of libido and early ageing. In this modem era, stress can disturb an individual’s normal physical and mental health. It causes the perturbation of the body's homeostasis and leads to various physical and psychological health problems. The state of accumulated stress can increase the risk of both acute and chronic psychosomatic illness and weaken immune system of the body. Stress can cause many things such as headaches, anorexia, insomnia, fatigue, or diseases such as hypertension, diabetes mellitus etc. Withania Somnifera is commonly known as Ashwagandha in Ayurvedic medicine, Indian ginseng, poison gooseberry or winter cherry. Well-known antioxidant or Rasayana drug has been chosen and selected for the management of chronic ailments like Tuberculosis and Diabetes mellitus associated with stress, anxiety, headache, insomnia, loss of energy, fatigue, loss of libido. It is used as an antioxidant, diuretic, sedative, anti-inflammatory and aphrodisiac for many ages. Many studies have shown that Withania Somnifera roots have several effects on the central nervous system, including modulation of acetylcholinesterase activity and serotonin receptors, as well as GABA activity (NPD, 2017). Ahmad et al. (2010) described a significant increase (P < 0.01) in sperm concentration and motility in men with normozoospermia, oligozoospermia, and azoospermia treated with Ashwagandha root extract. Results showed a decrease in seminal LPO levels, stress and serum cortisol levels, ROS production, elevated antioxidant levels and overall improvement in sperm quality (concentration and motility), testosterone and LH levels. The current study evaluates the efficacy of Ashwagandha as an antioxidant. Ashwagandha (Withania Somnifera) is already been clinically tried as an adjuvant in the patient with Tuberculosis and Diabetes mellitus. We have given Vedaan Ashwagandha, KSM 66 capsules in our OPD and IPD.