A Double Blind, Randomized, Placebo-Controlled Clinical Study of the Nutraceutical Ashwagandha in the Form of Vedaan Ashwagandha KSM 66 Capsules as an Antioxidant, Energy Booster, Nervine Tonic, Anti-Stress and Aphrodisiac in General and Specific Chronic Ailments

Dr. Ravi Raj, D. Kumar, Dr. Ameed Murad
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Abstract

In the modern world, numerous ailments like Tuberculosis and Diabetes Mellitus are common health problems. They can generate a loss of energy in the body, and develop neuropathies which can further generate stress, insomnia, loss of libido and early ageing. In this modem era, stress can disturb an individual’s normal physical and mental health. It causes the perturbation of the body's homeostasis and leads to various physical and psychological health problems. The state of accumulated stress can increase the risk of both acute and chronic psychosomatic illness and weaken immune system of the body. Stress can cause many things such as headaches, anorexia, insomnia, fatigue, or diseases such as hypertension, diabetes mellitus etc. Withania Somnifera is commonly known as Ashwagandha in Ayurvedic medicine, Indian ginseng, poison gooseberry or winter cherry. Well-known antioxidant or Rasayana drug has been chosen and selected for the management of chronic ailments like Tuberculosis and Diabetes mellitus associated with stress, anxiety, headache, insomnia, loss of energy, fatigue, loss of libido. It is used as an antioxidant, diuretic, sedative, anti-inflammatory and aphrodisiac for many ages. Many studies have shown that Withania Somnifera roots have several effects on the central nervous system, including modulation of acetylcholinesterase activity and serotonin receptors, as well as GABA activity (NPD, 2017). Ahmad et al. (2010) described a significant increase (P < 0.01) in sperm concentration and motility in men with normozoospermia, oligozoospermia, and azoospermia treated with Ashwagandha root extract. Results showed a decrease in seminal LPO levels, stress and serum cortisol levels, ROS production, elevated antioxidant levels and overall improvement in sperm quality (concentration and motility), testosterone and LH levels. The current study evaluates the efficacy of Ashwagandha as an antioxidant. Ashwagandha (Withania Somnifera) is already been clinically tried as an adjuvant in the patient with Tuberculosis and Diabetes mellitus. We have given Vedaan Ashwagandha, KSM 66 capsules in our OPD and IPD.
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一项双盲、随机、安慰剂对照的临床研究,以Vedaan Ashwagandha KSM 66胶囊的形式作为一般和特定慢性疾病的抗氧化、能量增强、神经滋补、抗应激和壮阳药
在现代社会,许多疾病,如肺结核和糖尿病是常见的健康问题。它们会导致身体能量损失,并导致神经病变,进而导致压力、失眠、性欲减退和早衰。在这个现代时代,压力会扰乱一个人的正常身心健康。它会扰乱人体的内稳态,导致各种生理和心理健康问题。累积的压力状态会增加急性和慢性心身疾病的风险,并削弱身体的免疫系统。压力会导致很多事情,比如头痛、厌食症、失眠、疲劳,或者高血压、糖尿病等疾病。Withania Somnifera在印度草药、印度人参、毒醋栗或冬樱桃中通常被称为Ashwagandha。众所周知的抗氧化剂或Rasayana药物已被选择和选择用于管理慢性疾病,如结核病和糖尿病与压力,焦虑,头痛,失眠,精力不足,疲劳,性欲丧失有关。它被用作抗氧化剂、利尿剂、镇静剂、消炎剂和催情剂,适用于许多年龄段。许多研究表明,Withania Somnifera根对中枢神经系统有多种影响,包括调节乙酰胆碱酯酶活性和血清素受体,以及GABA活性(NPD, 2017)。Ahmad等人(2010)描述了用Ashwagandha根提取物治疗无精子症、少精子症和无精子症患者的精子浓度和活力显著增加(P < 0.01)。结果显示,精子LPO水平、应激和血清皮质醇水平、ROS产生、抗氧化水平升高、精子质量(浓度和活力)、睾酮和LH水平总体改善。目前的研究评估了Ashwagandha作为抗氧化剂的功效。Ashwagandha (Withania Somnifera)已经在结核病和糖尿病患者中作为辅助治疗进行了临床试验。我们在OPD和IPD中给了Vedaan Ashwagandha, KSM 66胶囊。
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