Fast detection of sulcal regions for classification of Alzheimer’s disease and Mild Cognitive Impairment

Abstract

Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI) are neurogenerative impairments with similar symptoms and risk factors. Sulcal width and depth are known biomarkers for discriminating between AD and MCI. This paper presents a novel 2D image representation for a brain mesh surface, called a height map. The basic idea behind the height map is to represent the surface as a function of spherical coordinates of the mesh vertices. We present a method to derive a height map from a given neuroimage (MRI) and extract sulcal regions from the height map. We demonstrate the height map’s utility for classifying a given neuroimage into healthy, MCI and AD classes. Two approaches for extracting sulcal regions are explored. The proposed method is computationally light, and obtaining sulcal regions from a brain surface mesh takes about 24 seconds on a standard Intel i5-7200 CPU. The proposed method achieves 76.1% accuracy, and 76.3% F1-score for healthy, MCI, AD classification on a publicly available dataset.