Tailoring Polymeric Nanoparticles as Nanocarriers via RAFT Polymerization

S. Agustina
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Abstract

Polymeric nanoparticles are really promising to be used as drug carriers, due to its ability to increase the aqueous solubility of drugs. Polymeric nanoparticles can regulate the drug activity by passive or active targeting to different tissues. RAFT polymerization has become the most approvable technique to synthesize polymeric nanocarriers for drug delivery. By using different RAFT agents, wide ranges of polymeric nanoparticles with various architecture and water solubility can be obtained under mild conditions.
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通过RAFT聚合裁剪聚合物纳米颗粒作为纳米载体
由于聚合物纳米颗粒能够增加药物的水溶性,因此它很有希望被用作药物载体。聚合物纳米颗粒可以通过被动或主动靶向不同组织来调节药物活性。RAFT聚合已成为合成高分子纳米药物载体的最受认可的技术。通过使用不同的RAFT试剂,可以在温和的条件下获得具有不同结构和水溶性的大范围聚合物纳米颗粒。
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