On the purinergic system in rat duodenum: existence of P1 and P2 receptors on the smooth muscle.

A Postorino, R Serio, F Mulè
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引用次数: 6

Abstract

In rat duodenum, in vitro, in the presence of atropine and guanethidine, ATP administration caused a tetrodotoxin-insensitive relaxation followed by a rebound contraction. A similar response was obtained also after electrical field stimulation (EFS) of non-adrenergic, non-cholinergic (NANC) nerves. alpha, beta-methylene-TP and theophylline antagonized the response to ATP, but they failed to affect the noradrenaline- and EFS-induced relaxation. These results suggest that P1 and P2 receptors are present in rat duodenum, but their activation is not responsible for the inhibitor effects due to the NANC nerves.

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大鼠十二指肠嘌呤能系统:平滑肌上存在P1和P2受体。
在离体大鼠十二指肠中,在阿托品和胍乙啶存在的情况下,ATP给药引起河豚毒素不敏感的松弛,随后是反弹收缩。电场刺激非肾上腺素能、非胆碱能神经(NANC)后也有类似的反应。α、β -亚甲基- tp和茶碱能拮抗ATP的反应,但不能影响去甲肾上腺素和efs诱导的松弛。这些结果表明P1和P2受体存在于大鼠十二指肠,但它们的激活不是NANC神经抑制作用的原因。
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