Frequency of red blood cells antibodies in possible cases of hemolytic disease of the newborn laboratory evidenced at Hemopa

Flávia Alcantara Coutinho, Fabiana Regina Ribeiro Carvalho, Maristela Gonçalves de Carvalho, Regiane Siqueira de Vilhena, I. Pinto, Bruna Pedroso Tamegão Lopes Cavalleiro de Macedo, Renata Bezerra Hermes de Castro
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Abstract

Purpose: To describe the frequency of red blood cells antibodies possibly related to Hemolytic Disease of the Newborn cases reported laboratory evidenced at Fundação Centro de Hemoterapia e Hematologia do Pará. Methods: This is a descriptive, cross-sectional study, based on the analysis of immuno-hematological reports of newborns filed at the Immunohematology Laboratory of the Fundação Centro de Hemoterapia e Hematologia do Pará , released between January 2015 and December 2019. The obtained data are related to ABO/Rh(D) typing; Direct Antiglobulin test; Irregular Antibodies test; Eluate, which were transcribed to Microsoft Excel sheets for later descriptive analysis. The study was approved by the Research Ethics Committee of the Fundação Pública Estadual do Hospital das Clínicas Gaspar Vianna, under the legal opinion #3,435,869. Results: A total of 37 reports were analyzed, laboratory evidence showed 34 cases of positive Direct Antiglobulin Test, of these, 22 presented positive eluate test. The highest frequency of described cases was related to anti-D antibody (19/22; 86.4%), followed by anti-c (1/22; 4.5%) and clinically significant antibody associations (2/22; 9.1%). Conclusion: The most frequent alloantibody evidenced was anti-D, however, other red blood cells alloantibodies observed drew attention and were considered relevant scientific evidence regarding the subject.
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血红细胞抗体在新生儿溶血性疾病可能病例中的频率在血友病实验室证实
目的:描述在 医院血液病中心和旁血液病中心报告的新生儿溶血性疾病可能相关的红细胞抗体的频率。方法:这是一项描述性横断面研究,基于对2015年1月至2019年12月期间在 血液中心免疫血液学实验室提交的新生儿免疫血液学报告的分析。获得的数据与ABO/Rh(D)分型有关;直接抗球蛋白试验;不规则抗体试验;这些数据被转录到Microsoft Excel表格中,以供以后的描述性分析。这项研究得到了Clínicas加斯帕尔·维亚纳医院 基金会研究伦理委员会(Clínicas Gaspar Vianna Estadual Hospital)根据第3 435 869号法律意见批准。结果:共分析37例报告,实验室证据显示直接抗球蛋白试验阳性34例,其中洗脱试验阳性22例。所描述病例的最高频率与抗d抗体有关(19/22;86.4%),其次是anti-c (1/22;4.5%)和临床显著的抗体相关性(2/22;9.1%)。结论:最常见的同种异体抗体为抗d抗体,但观察到的其他红细胞同种异体抗体引起了人们的注意,并被认为是与本课题相关的科学证据。
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